Companies receive HHS orders for novel flu vaccine

first_imgMay 26, 2009 (CIDRAP News) –Two vaccine companies, Sanofi Pasteur and GlaxoSmithKline, recently announced they received their first orders from the US government for a vaccine and adjuvant to protect the country against the novel H1N1 virus.Sanofi, in a statement released yesterday, said the initial order it received from the Department of Health and Human Services (HHS) covers the production of bulk vaccine and related activities and is worth $190 million. On May 22, Glaxo said in a press release that HHS ordered vaccine antigen and the company’s proprietary adjuvant system, AS03. Adjuvants are compounds that enhance a vaccine’s immune response, offering the possibility of stretching antigen supplies.The announcements from the two companies follow a May 22 announcement from HHS that secretary Kathleen Sebelius was directing about $1 billion in existing funds toward clinical studies and commercial production of bulk vaccine antigen and adjuvant.Federal officials have announced plans to support the development of a novel H1N1 vaccine, but have taken pains to explain that the decision to use it would be made separately.The Centers for Disease Control and Prevention (CDC) has said it hopes to wrap up work on a seed strain to send to vaccine makers within the next few weeks. Once companies receive the seed strain, they can develop pilot lots to begin safety, efficacy, and dosage testing.The federal government’s placement of the orders falls under existing contracts that the Biomedical Advanced Research and Development Authority (BARDA) established with the companies in 2004 as part of the nation’s pandemic influenza strategy.Sanofi said it hopes to begin work on a pilot lot in June after the US Food and Drug Administration approves its working seed. The company said clinical trials could begin as early as August, but a timeline for final formulation, filling, and distribution has not been set.Wayne Pisano, Sanofi’s president and chief executive officer, said in the press release that though a number of complex steps need to be taken before a vaccine is available, the company’s experience in developing the prepandemic H5N1 avian influenza vaccine will be helpful. “We look forward to further demonstrating our experience and expertise in vaccine development as we prepare for this new threat from AH1N1,” he said.Production of the new H1N1vaccine for HHS will take place at the company’s recently licensed new production facility in Swiftwater, Pa. As soon as the company finishes production of seasonal influenza vaccine at its second Swiftwater facility, it can produce the novel H1N1 vaccine at both plants. The two plants, when operating at full capacity, can make about 150 million doses of seasonal flu vaccine.Meanwhile, Glaxo said it expects to fill HHS’ adjuvant order within the next few months and hopes to produce the first antigen doses 4 to 6 months after receiving the novel H1N1seed strain. The company said its proprietary adjuvant, already approved as a component of the H5N1 vaccine in Europe and some Asian countries, is the subject of 15 additional clinical trials, including one involving a seasonal flu vaccine.Both Sanofi and Glaxo said they are in ongoing discussions with other countries about producing novel flu vaccine for national stockpiles.See also:May 25 Sanofipress releaseMay 22 Glaxopress releaseMay 22 HHS press releaseMay 6 CIDRAP News story “FDA approves new vaccine facility”last_img read more

Tablets a hit with kids, but experts worry

first_img3News 25 December 2013Tablet computers are so easy to use that even a three-year-old can master them.And that has some paediatricians and other health experts worried.Since navigating a tablet generally doesn’t require the ability to type or read, children as young as toddlers can quickly learn how to stream movies, scroll through family photos or play simple games.That ease-of-use makes tablets -and smartphones- popular with busy parents who use them to pacify their kids during car rides, restaurant outings or while they’re at home trying to get dinner on the table. And many feel a little less guilty about it if they think there’s educational value to the apps and games their children use.The devices are expected to rank among the top holiday gifts for children this year. Gadget makers such as Samsung have introduced tablets specifically designed for kids and many manufacturers of adult tablets now include parental controls. Those products are in addition to the slew of kiddie tablets produced by electronic toy makers such as LeapFrog, Vtech and Toys R Us.But some experts note there’s no evidence that screen time – whether from a TV or tablet – provides any educational or developmental benefits for babies and toddlers. Yet it takes away from activities that do promote brain development, such as non-electronic toys and adult interaction.http://www.3news.co.nz/Tablets-a-hit-with-kids-but-experts-worry/tabid/421/articleID/326368/Default.aspxlast_img read more

Cricket News IPL 2019: Jayant Yadav traded to Mumbai Indians from Delhi Capitals

first_imgNew Delhi: Jayant Yadav, the 28-year-old offspinner who played four Tests and and ODI during the 2017 season, will play for three-time IPL champions Mumbai Indians after he was traded from the Delhi Capitals side following the end of the 2019 Indian Premier League auctions. Yadav, who was part of the Delhi franchise since 2015, has played in just 10 IPL games and last represented India in February 2017. The trading window remains open until 30 days to the start of the 2019 Season. Yadav, who currently plays for Haryana in domestic cricket, recently represented India in the Emerging Teams Cup in Colombo when he picked up 10 wickets in five games.Yadav put in a solid performance during the series against England. He slammed his first fifty in the Test match in Mohali while in the Mumbai Test, he blasted a century while batting at No.9. Jayant became the first Indian No.9 batsman to score a Test century and his 241-run stand with Kohli, a record for the eighth wicket, took the game away from England as India won the series 4-0.Read More | Varun Chakaravarthy reveals his excitement to play for KXIPThe right-hander played one solitary ODI during the Vizag game against New Zealand in 2017 and he ended with figures of 1/8 in four overs as India thrashed New Zealand by 190 runs to clinch the ODI series 3-2.Read More | IPL 2019 Auction: Say hello to these ‘unknown’ millionairesHowever, following the Pune Test against Australia in 2017, Yadav proved to be ineffective on a rank turner. He ended up with an economy rate of over 4.5 in both the innings and picked up only two wickets in the entire match. His expensive economy rate was one of the reasons for India to lose the match by a massive margin of 333 runs. In that match, Steve O’Keefe picked up the best haul by a spinner against India as he ended with figures of 12/70 (6/35 in both innings) as Australia won a Test in India after 13 years. Following the result, Yadav was dropped from the team and has not been picked since.The Indian Premier League 2019 auctions were conducted on December 18 in Jaipur and 60 players went under the hammer. Jaydev Unadkat and Varun Chakaravarthy were the biggest gainers in the auction, with Rajasthan Royals and Kings XI Punjab acquiring both players for Rs 8.4 crore respectively. For all the Latest Sports News News, Cricket News News, Download News Nation Android and iOS Mobile Apps.last_img read more

AFCON 2017 Qualifier: Adam Kwarasey returns for Black Stars as Andre Ayew misses out

first_imgAvram Grant has named a 23-man squad for this month’s 2017 AFCON qualifiers against Mozambique.The Black Stars head coach excluded deputy captain Andre Ayew and Phil Ofosu-Ayeh from the squad because of injuries.Adam Kwarasey and Alfred Duncan return to the squad while captain Asamoah Gyan and Mubarak Wakaso were named.The first of the two back-to-back matches will be played at the Accra Stadium on Thursday March 24 at 3:30pm.The return leg is scheduled for Maputo three days later.Ghana are top of Group H with maximum six points from the two matches in the group. Below is the full 23-man squad:Goalkeepers:Razak Braimah (Cordoba, Spain)Adam Kwarasey(Portland Timbers, USA)Richard Ofori (Wa All Stars) Defenders:Harrison Afful (Columbus Crew, USA)Daniel Amartey, (Leicester City, England)Jeffery Schlupp (Leicester City, England)Baba Rahman (Chelsea, England) John Boye (Sivasspor, Turkey)Jonathan Mensah (Anzhi, Russia)Gyimah Edwin (Orlando Pirates, South Africa)Midfielders:Rabiu Mohammed (Krasnodar, Russia) Emmanuel Agyemang-Badu (Udinese, Italy)Afriyie Acquah (Torino, Italy), Samuel Tetteh (WAFA)Mubarak Wakaso (Las Palmas, Spain Fire, USA)Frank Acheampong (Anderlecht, Belgium)Alfred Duncan (Sussualo, Italy) Christian Atsu (Malaga, Spain)Forwards:Asamoah Gyan (SIPG Shanghai, China)Jordan Ayew (Aston Villa, England)Abdul-Majeed Waris (Lorient, France) Ebenezer Assifuah (Sion, Switzerland)David Accam (Chicago Fire, USA)–Follow Joy Sports on Twitter: @JoySportsGH. Our hashtag is #JoySportslast_img read more