Preventing Aging Through Darwin-Free Science

first_img These discoveries suggest more amazement ahead.  “The v-ATPase consists of multicomponent V0 and V1 domains and operates through an incompletely understood mechanism in which each cycle of ATP hydrolysis by the V1 sector generates torque that rotates the membrane domain of V0, known as the rotor,” is how the researchers in the last entry above described the machine.  “In turn, this movement enables the transfer of protons into the lysosomal lumen, causing its acidification.”  Later in the paper, they added, “The v-ATPase is large and complex and has many functions that cannot easily be teased apart in live cells.”  It appears many more fascinating discoveries about cellular machines await. Does anyone really need commentary after this?  These stories, that owed nothing to Darwin, speak for themselves.  His Victorian mystery religion would have been a distraction.  None of these papers even mentioned evolution: the focus was on elegant engineering, quality control, machinery, process management, and hope for a better life through good old empirical research.  Imagine if Aristotle, Descartes or Leeuwenhoek would have seen what we are seeing now.  Rotary engines!  Checkpoints!  Multi-sensory inputs!  Signaling circuits!  If you are not already thankful, you should be.(Visited 20 times, 1 visits today)FacebookTwitterPinterestSave分享0 Will new discoveries in biochemistry lead to longer lives?  There are hopeful signs that aging can be delayed, if not prevented.  Whether or not that happens in our lifetimes (causing new worries for Social Security), scientists are learning amazing things about how cells work that should give us more reason for Thanksgiving. 100-year-old youth:  Get this. Skin cells taken from donors aged 74 to 101 have been returned to newborn youth, using the induced pluripotent stem cell (iPSC) method of reprogramming cells to the pluripotent state.  According to Science Daily, signs of aging were “erased” in these cells.  They “recovered their capacity for self-renewal and their former differentiation potential, and do not preserve any traces of previous aging.”  This means that age is not a barrier to reprogramming.  Elders can imagine a fountain of youth: “This research paves the way for the therapeutic use of iPS, insofar as an ideal source of adult cells is provided, which are tolerated by the immune system and can repair organs or tissues in elderly patients.” Your personal fountain of youth:  If your own skin cells can be rejuvenated fresh as a baby, why not bank them?  In “Personal Stem Cell Banks Could Be Staple of Future Health Care,” Science Daily discussed that very possibility.  Researchers at the University of Texas Health Science Center found that old stem cells can be rejuvenated by placing them in a young microenvironment.  “This raises the possibility that patients’ own stem cells may one day be rescued and banked to treat their age-related diseases.”  The Texans were apparently unaware of the work cited above that shows even centenarians donating cells that can be regenerated like new: “Older stem cells are not as robust as young ones,” this article claimed.  If they are robust, why not store them like gold for a rainy day? Eternal cells:  Ever since telomeres (like caps on the ends of chromosomes) were found to act as a countdown mechanism for cell division, researchers have been eager to know if their lifetimes can be extended.  There is an enzyme, telomerase, that puts new telomeres on chromosomes, but usually just in embryonic cells.  Medical Xpress reported that scientists at the German Cancer Research Center have found an alternate pathway for telomere lengthening.  Research shows that some cancer cells use this alternate mechanism; that is why they keep dividing without limit.  Learning how to prolong telomeres for good cells and arrest them for tumor cells is an important work in progress (see 9/25/2010). Checking checkpoints:  Having checkpoints makes for good quality control in any engineering process.  Remarkably, cells have checkpoints, too.  Science Daily reported on work at the University of Warwick to study the “spindle checkpoint” in cell division that determines “How Daughter Cells Receive the Same Number of Chromosomes.”  When that checkpoint is breached, aggressive cancer can result.  The article quoted a member of the research team who said, “This cell division process is monitored by the body’s surveillance system known as the ‘spindle checkpoint’, and that is only switched off once everything within the cell is set up correctly. Amazingly, all of the elements of this process are conserved from yeast to human cells.”  Much of biomedical research concerns finding ways to repair mutations to processes that were already there to prevent harm. The navigators:  You don’t have to put a pyramid over your head, according to another article on Science Daily; you already have pyramid-shaped neurons in your cerebellum called “place cells” with a natural alternative to psychic powers.  “Each place cell is activated at specific location of the environment and gives dynamic information about self-location relative to the external world,” the article said.  “These neurons thus generate a cognitive map in the hippocampal system through the integration of multi sensory inputs combining external information (such as visual, auditory, olfactory and tactile cues) and inputs generated by self-motion (i.e. optic flow, proprioceptive [sense of limb position] and vestibular [inner-ear] information).”  Scientists at Ruhr University learned this from mice, but it’s probably true of mice and men, and women, too. Internal sunscreen for that young look:  Tanning: we’ve been warned too much is harmful.  But the melanin in skin and eyes that darkens us upon exposure to ultraviolet light helps protect us, too.  Medical Xpress said that while it takes days for UVB light to give that beach bronze look, our skin reacts much quicker to the more dangerous UVA – even within seconds.  In the skin and the eye, with rhodopsin assisting, melanin production is triggered, absorbing UVA before it can lead to oxidative damage, and “converting it to a less harmful energy in the form of heat.”  That’s what artificial sunscreens try to do anyway.  Thankfully, your skin has heat sensors that remind you to get out of the sun. Rotary teamwork:  ATP synthase made the news again in another wonderful way.  The little rotary engines that generate ATP (the cell’s energy currency) work with other components that lubricate them.  Science Daily reported work at Oxford University that learned how fatty acids interact with the engines.  Sure enough, they “act as a ‘lubricant’ for the motor,” the scientists said. Maybe that gives the edge for the grand prize of 100% efficiency (see 10/14/2011). Rotary recycling:  A cousin of ATP synthase is vacuolar ATP synthase (v-ATPase).  It has the same rotary structure but spends ATP to pump protons into vacuoles and lysosomes, creating acidic conditions where cells break down and recycle used parts.  In Science this week (334:6056, 11/04/2011, pp. 678-683, doi:10.1126/science.1207056), Zoncu et al. found an unexpected connection between v-ATPase and a protein complex in lysosomes named mTOR that is a “master growth regulator that is stimulated by amino acids.”  Elaborating on its important role, they said, “This multicomponent protein kinase integrates inputs from growth factors as well as nutrient and energy supplies to control many biosynthetic and catabolic processes.”  The team discovered that the rotary motor v-ATPase is intrinsically involved in an amino-acid signaling process that causes the mTOR complex 1 to translocate to the organelle surface.  “These results identify the v-ATPase as a component of the mTOR pathway and delineate a lysosome-associated machinery for amino acid sensing,” the researchers said, thus recognizing v-ATPase having a more sophisticated role than just a proton pump. Apparently, the accumulation of amino acids in the lumen of the lysosome activates the motors to pump protons.  This, in turn, puts the mTOR complex into action.last_img read more

Nigeria crowned Africa’s best on sand

first_imgTwo goals down at the first break, and a player down, it could have spelt the end of Cote d’Ivoire’s hopes before the start of the second period. The extra three minutes produce a goal apiece, with Djimi looking like he had clinched victory for the central Africans with his hat-trick goal, only for Rashid Mohamed to level matters and take the game to a penalty shootout. In the first period the combination shared the goals, with Olawale getting the first and third, both set up by Yahaya, while his partner got the second, to leave Nigeria in control with a 3-1 lead at the first break. The teams then swopped goals as the game ebbed and flowed at a fast pace. The final break was signalled with Cote d’Ivoire 5-4 ahead after Salomon Ouraga got on the scoresheet and Djimi completed a hat-trick, while Moustafa Abdelrahman and Ahmed replied for Egypt. SA’s opponentsMorocco went on to thrash Mozambique 9-3 to finish fifth, while Senegal were edged out by the champions, Nigeria, in the semi-finals, going down 7-6 after leading 4-1 heading into the second period. Despite both teams going at it hammer and tongs in the second period, neither was able to score as a combination of wayward shooting, great goalkeeping, and some bad luck prevented any change to the score taking place. The play swung back and forth, and even though Cote d’Ivoire managed to pull edge the third period, another Olawale goal took the final tally to 7-4 to Nigeria. Third place playoffLast year’s champions Senegal faced Egypt in the playoff for third and fourth place. Two early goals by the Senegalese, which put them 2-0 ahead after only 90 seconds, proved to be the difference in the game. While the Nigerians beat the Senegalese, it took an astonishing finish to take them into the final. While the 2007 champions appeared to be the better side out on the sand, the scoreboard after the first period did not reflect that at all. Scoring against the run of play, Senegal enjoyed a 4-1 lead. It was a tight contest heading into the final period, with Senegal only 3-2 ahead, but they pulled 6-3 ahead before Mohammed Rashid scored a late consolation goal for the Egyptians. SAinfo reporter The match was played at a hectic pace, with no let up, and both teams going all out to take control as play swung from end to end. With shots raining in on both goalkeepers, either team could have scored numerous times before Cote d’Ivoire got the first breakthrough – but the opening goal came seconds after a missed chance at the other end. Both teams had already qualified for the Beach Soccer World Cup by making it into the title decider. After the match there was some consolation for Cote d’Ivoire as their goalkeeper Kevin Enam was named the Goalkeeper of the Tournament. Nigeria’s win came on the back of a superb defensive performance, most notably by Ogbonnaya Okemirri who was rock solid in containing the Cote d’Ivoire strikers. From villain to heroThe match between the Cote d’Ivoire and Egypt saw Ivorian goalkeeper Kevin Enam go from villain to hero. Egypt equallised a minute into the final period when Ahmed scored his third, and he netted his fourth from the penalty sport 90 seconds later, to put the Sand Pharaohs ahead. The semi-finals had produced two thrilling contests. In an absolute humdinger, Nigeria sneaked past Senegal by seven goals to six, while Cote d’Ivoire overcame a disastrous first period to oust Egypt in a penalty shootout after the teams had ended regulation time level at 8-8. He was firstly shown a yellow card after he tried to gain some ground on a free kick after being warned not to, and he then deliberately tripped opposition goalkeeper Mohamed Issa, who already had the ball safely in his hands, to be shown red. Would you like to use this article in your publication or on your website? See: Using SAinfo materialcenter_img A pinpoint shot into the bottom corner from Elahalim gave the Egyptians hope of a place in the final, but Ehounou, only seconds after being booked for incessantly chirping the referees, was able to take the match into extra time. Third periodIn the third period, Senegal opted to defend their lead and they paid dearly for it as Nigeria were able to run at them and create opportunities. Within a minute the lead was reduced to two goals, after Yahaya drew a foul and smashed the resulting free kick home. Then, a flurry of four goals within only 90 seconds turned the match on its head. Isiaka Olawale netted twice to even the scores and Baba struck to put Nigeria ahead for the first time. However, the lead lasted just 35 seconds before Jean Koupaki pulled Senegal back on level terms again. Goal blitzBut a blitz of three goals within two minutes of the start of the second period, one from Ludovic Ehounou and two from Landry Djimi, put the Ivorians ahead. From that point onwards, the goals were shared, with both teams netting four times. Mourtada Ndour starred for the winners, scoring four times. South Africa failed to advance beyond the group stage, but pre-tournament predictions that the host’s group was the toughest were proved correct. SA went down to Morocco in their opening match and then fell 7-6 to the defending champions Senegal after extra time. 7 July 2009 The well organised and slick Egyptians were given a further boost they could not have dreamed of a couple of minutes later when inspirational Cote d’Ivoire star and playmaker Frederic Aka was red carded following two instances mindless stupidity. First semi-finalIn the first match, Nigeria fought back from three goals down to edge past Senegal 7-6, and then, just when spectators though that spectacle could not be bettered, Cote d’Ivoire overcame a disastrous first period to oust Egypt in a penalty shootout after the teams ended the regulation time at 8-8. The second stanza was almost identical to the first, except that Cote d’Ivoire were able to get on the score sheet again with only 40 seconds of the period left when Thomas Ehounou scrambled the ball into the net. Enam gained the plaudits after the match following his penalty save of Ahmed Hany’s kick, which secured the win for his side, but earlier in the contest he was cast in a less favourable light after the unique challenges of playing football on a beach exposed him twice. In the first period he was beaten by two shots, from Almoataz Elahalim and Ahmed Ahmed, both of which bounced bizarrely off the uneven sand and beat him. Nigeria’s Olawale picked up two big awards – Player of the Tournament and Top Goal Scorer. Lead doubledBefore his strike, it was once again Olawale and Yahaya who were giving the Ivorian defence a tough time. They both scored again, while Victor Tale also found the back of the net. At the end of the second period, the Nigerians had doubled their advantage to 6-2. Egypt kept their lead for six minutes until Ouraga somehow managed to squeeze a goal from a sandy scramble in the goalmouth with only four minutes remaining in the game. Cote d’Ivoire leadDidier Kabletchi netted the first for Cote d’Ivoire from a quick break after Nigerian Isiaki Olwale had mis-kicked with a wide open goal in front of him at the other end of the park. However, from that point on Nigeria took command, with the front running duo of Olawale and Baba Yahaya combining brilliantly to bamboozle the stressed Cote d’Ivoire defence. Olawale scrambled the ball into the net from a melee in front of the goals to level things up once more with just over three minutes to play. Then, in contrast to his first two goals which were rocketed into the net, he displayed a delicate touch to guide the ball into the corner and away from the outstretched arms of keeper Ndiaye Al Seyni. Nigeria were crowned African champions when they beat Cote d’Ivoire 7-4 in a thrilling final of the Africa qualifiers for the 2009 Fifa Beach Soccer World Cup in Durban on Sunday. It was a second title for the West African powerhouse, following their success in 2007. With only five minutes left in the match, Koupaki slotted his second to take Senegal back into the lead. Instead of sticking to what had worked for them, the defending champions opted to once more defend their lead. It didn’t work. last_img read more

Moroccan Woman Arrested for Trying to Smuggle 2300g of Cocaine

first_imgCasablanca- Customs officers in Casablanca’s Mohammed V Airport arrested on Saturday a Moroccan citizen coming from São Paulo (Brazil) after she had attempted smuggling 2300 grams of cocaine.According to news website Le360, a Moroccan citizen coming from São Paulo attempted to smuggle 2300 grams of cocaine in Mohammed V Airport in Casablanca, before her attempt was thwarted by custom officers.According to the same source, the police found that the suspect, a 39-year-old woman, tried to smuggle the 2300 grams of cocaine in three separate jam jars. The suspect used to travel frequently between Morocco and Brazil, where her husband lives.© Morocco World News. All Rights Reserved. This material may not be published, rewritten or redistributedlast_img

No restorations planned during Erika if power fails FortisTCI says after all

first_imgFacebook Twitter Google+LinkedInPinterestWhatsAppProvidenciales, 28 Aug 2015 – One of the biggest concerns in a storm is whether or not the power will remain on; FortisTCI’s office closed early today and advised that it has completed its disaster preparedness procedures and will supply power to its customers to the extent possible during the storm.The company also reminds that once Erika has passed, that we ought to stay away from any downed power lines.Once the all clear is given, FortisTCI says the company will immediately commence restoration efforts. Rave Reviews for National Science Fair ideas Related Items:fortis tci, power, ready FortisTCI reveals Education Week winners Facebook Twitter Google+LinkedInPinterestWhatsApp Recommended for you TCI Police looking for candy & electricity thieveslast_img read more

Rui Vitória Little duels will make a difference for Benfica

first_imgBenfica boss Rui Vitória is aware of the offensive quality tonight’s Champions League opponents Ajax contain and feels that the “little duels” could prove decisiveThe Eagles bounced back from an opening game defeat to Bayern Munich by claiming a 3-2 win over AEK Athens in Greece last time out in Group E.Benfica head into tonight’s game at the Amsterdam Arena in good form following a 1-0 win against rivals FC Porto two weeks ago before following it up with a 3-0 win over Sertanense in the Taça de Portugal last week.Vitória’s side leads the Primeira Liga alongside Braga on 17 points and are unbeaten after seven games.But their coach is remaining cautious over Ajax as Benfica look to extend their winning run to four games in all competitions.“We are aware that Ajax, from an offensive point of view, are a team with many dynamics, but we will have our ambition,” Vitória told reporters on Twitter.“Quality on one side, quality of the other, the little duels will make a difference. So we must concentrate and be thorough in the game. Naturally, we will have to defend and create problems for Ajax.”Dusan tadic, AjaxReport: Ajax are top of the league after 4-1 win George Patchias – September 15, 2019 Ajax is top of the Eredivisie after beating Heerenveen 4-1.Ajax was without standout midfielder Donny van Beek again, for the visit of Heerenveen to…He added: “It’s fundamental to realize the dynamics that Ajax players have.“The plan is to block these dynamics and look to impose our game when we have the ball.”Benfica are third in Group E and a point behind leaders Ajax and Bayern on three points.😐 😜 😆 😅— SL Benfica (@slbenfica_en) October 18, 2018last_img read more

Pochettino Trophies only build ego

first_imgMauricio Pochettino does not believe winning trophies will automatically take Tottenham to the next level.Spurs woes were compounded with a 2-0 defeat at Crystal Palace in the FA Cup fourth round after losing to Chelsea in the Carabao Cup semi-final inside four days.However, the Argentine boss is not losing focus on Spurs as he is adamant trophies will not weave the magic overnight.“Again we’re going to have the debate on whether a trophy will take the club to the next level. I don’t agree with it. It only builds your ego. The most important thing for Tottenham right now is to always be in the top four.”He added via Sky: “It’s true, this season has been tough. I told you it would be a massive challenge for us, but we believe it’ll be a tough season but no tougher than it’s been.🗣️ The post-match thoughts of Mauricio at Selhurst Park:— Tottenham Hotspur (@SpursOfficial) January 27, 2019“Of course, disappointed because, after Thursday and today again, out of two competitions. You feel disappointed. You can’t feel anything different.Victor Wanyama, Tottenham Hotspur, Premier LeaguePochettino admits Wanyama remains in his Spurs plans Manuel R. Medina – September 14, 2019 Kenyan international, Victor Wanyama, was the protagonist of a summer transfer saga, but in the end, he is set to stay at Tottenham Hotspur.“But now we have to be positive. We are still in two competitions, in a good position in the Premier League and the Champions League is a massive motivation for the whole club. We have to be strong.“People wish we could win some trophies. But being realistic, we are doing so well. To win a title here in England like the FA Cup or Carabao Cup is about being lucky, not only about quality in your squad.“To arrive here in different condition, so you can fight or be stronger… Of course, it’s tougher to compete and win when things happened as they did.“Sometimes when you assess football, you only look at which team won and which team lost, but you have to consider all the circumstances.“Now the realistic targets are trying to be in the top four, try and be close to Manchester City and Liverpool and reduce the gap.“To be a contender is always difficult for us. [Top four] is realistic. Another is to try and beat [Borussia] Dortmund and be in the next round. That is tough.”FULL-TIME: We’re unable to find a way back into the game and our @EmiratesFACup run comes to an end at Selhurst Park.— Tottenham Hotspur (@SpursOfficial) January 27, 2019last_img read more