Baylor College of Medicine and Department Summary:The Michael E. DeBakey Department of Surgery and Baylor College ofMedicine are committed to excellence in surgical care, educationand research. Ideally situated in the heart of the world’s largestmedical center, the 150 members of the Department practice in theTexas Medical Center at iconic institutions, including BSLMC, TexasChildren’s Hospital, Ben Taub General Hospital, and the Michael E.DeBakey VA Medical Center.The BCM Division of Cardiothoracic Surgery performs a high volumeof adult cardiac operations annually at three affiliated hospitals.BSLMC, also home to the Texas Heart Institute (THI), is a renownedquaternary medical center with a pioneering tradition incardiovascular surgery. Substantial resources will be available tothe successfully recruited candidate to further grow and develop anationally prominent clinical and research program in adult cardiacsurgery. The Division trains 15 cardiothoracic surgery residentsand advanced cardiac surgery fellows and maintains a robustresearch program in clinical, translational, and basic scienceresearch.SummaryThe Division of Cardiothoracic Surgery in the Michael E. DeBakeyDepartment of Surgery at Baylor College of Medicine (BCM) is aseeking a Chief of cardiothoracic surgery to help lead the adultcardiac surgery program at the Baylor St. Luke’s Medical Center(BSLMC).Ideal candidates will have an established track record of clinicalexcellence in cardiac surgery with incorporation of innovativesurgical techniques, including minimally invasive cardiac surgery,all-arterial coronary artery bypass surgery, aortic surgery, and/ortranscatheter and endovascular procedures. Candidates should have astrong commitment to teaching cardiothoracic surgery residents andadvanced fellows and leading clinical and translational researchefforts.ABTS board certification or board eligibility is required and thecandidate must qualify for a full and unrestricted Texas medicallicense. An established track record in clinical research ispreferred.Enthusiastic applicants seeking a perfect balance of excellence inpatient care and a wide range of opportunities for scholarlyactivities should upload the following for consideration:curriculum vitae, narrative description of clinical, research andacademics, as well as resident teaching experience and a list ofreferences.Baylor College of Medicine is an Equal Opportunity/AffirmativeAction/Equal Access Employer.2317CA; CH
4SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblr Despite slowdowns in a number of economic indicators in the first quarter, credit union loan and membership growth posted solid gains in March, according to CUNA’s monthly estimates.Loan growth rose by 0.6% in March and climbed 10.6% on a year-over-year basis. Fixed-rate first mortgages drove the increases with a 3.1% jump, followed by new-auto loans (1.1%) and used-auto loans (1%).Further, between March 2014 and 2015, fixed-rate first-mortgage lending and new-auto lending accelerated by 6.8% and 22.6% respectively.“Recent economic data suggest slower U.S. economic expansion in the first quarter of this year,” said Perc Pineda, CUNA senior economist. “Credit unions, however, continue to experience increased activity.” continue reading »
“I will never forget his performance in Moscow, which was instrumental in winning us qualification for Euro 2012. “Richard and his family, particularly his parents Dick and Phyllis, will always be welcome guests in Aviva Stadium. “On behalf of the Association, I would like to wish him and his family the very best for the future.” Republic of Ireland defender Richard Dunne has announced his retirement from international football. Dunne is currently on tour in Ireland with the QPR squad as they prepare for a return to the Premier League. The west London side have friendly matches against Shamrock Rovers on Saturday and Athlone Town on Tuesday. He continued: “I have represented Ireland since I was 15 years of age, and have thoroughly enjoyed all the highs and lows that have come with playing for my country. “I will continue to support the team as they embark upon their new campaign under Martin O’Neill, and have every faith that they will qualify for France 2016. “I’d like to thank everyone I worked alongside during my time with Ireland, from managers, to players, to backroom staff. I have so many great memories that will stay with me forever.” Republic boss O’Neill said: “Richard has been a remarkable player for both club and country. “I had the pleasure of working with him at Aston Villa, where he had a big influence on the field. “He has consistently given 100 per cent every time he has been called on by his country also. I wish him all the best in his club career.” Football Association of Ireland chief John Delaney said: “Richard has been a tremendous servant to his country and is truly a player for Ireland to be proud of. Press Association The 34-year-old QPR player made his debut for his country in 2000, going on to win 80 caps, the last of which came against Kazakhstan last October. Dunne told his club’s official website: “Retiring from international football has been an extremely difficult decision for me to make.”
“Clearly, the relationship between Team Wilder and Team Joshua is not the best. I think this is a route that is going to be very beneficial to the making of that undisputed fight. It’s not just about doing a deal with Wilder, it’s about doing a deal with Joshua.”They’ve got their work cut out, but the pieces are coming together. There’s a long way to go but we’ll see where it goes. Now I think there’s a strategy in place that could lead us to this fight.”There’s a clear desire from both sides to make the fight.” Eddie Hearn is optimistic a deal can be agreed for Anthony Joshua to fight Deontay Wilder, stating “the pieces are coming together.”Joshua will make his United States debut at Madison Square Garden on June 1, but Jarrell Miller will be his opponent after terms could not be agreed for a heavyweight unification bout with Wilder. Wilder has been ordered to defend his WBC title against Dominic Breazeale after Tyson Fury opted to face another opponent before a potential rematch with the “Bronze Bomber.”Join DAZN and watch Joshua vs. Miller plus more than 100 fight nights a yearHearn, Joshua’s promoter, is hopeful an agreement can finally be reached for the WBA, WBO and IBF champion to do battle with Wilder, but it will be anything but straightforward.”It’s very encouraging,” Hearn told Sky Sports. “I’m not going to say too much on it, because I don’t want to jinx anything. But I think there’s an opportunity there for someone to be a mediator to get the fight done.
These discoveries suggest more amazement ahead. “The v-ATPase consists of multicomponent V0 and V1 domains and operates through an incompletely understood mechanism in which each cycle of ATP hydrolysis by the V1 sector generates torque that rotates the membrane domain of V0, known as the rotor,” is how the researchers in the last entry above described the machine. “In turn, this movement enables the transfer of protons into the lysosomal lumen, causing its acidification.” Later in the paper, they added, “The v-ATPase is large and complex and has many functions that cannot easily be teased apart in live cells.” It appears many more fascinating discoveries about cellular machines await. Does anyone really need commentary after this? These stories, that owed nothing to Darwin, speak for themselves. His Victorian mystery religion would have been a distraction. None of these papers even mentioned evolution: the focus was on elegant engineering, quality control, machinery, process management, and hope for a better life through good old empirical research. Imagine if Aristotle, Descartes or Leeuwenhoek would have seen what we are seeing now. Rotary engines! Checkpoints! Multi-sensory inputs! Signaling circuits! If you are not already thankful, you should be.(Visited 20 times, 1 visits today)FacebookTwitterPinterestSave分享0 Will new discoveries in biochemistry lead to longer lives? There are hopeful signs that aging can be delayed, if not prevented. Whether or not that happens in our lifetimes (causing new worries for Social Security), scientists are learning amazing things about how cells work that should give us more reason for Thanksgiving. 100-year-old youth: Get this. Skin cells taken from donors aged 74 to 101 have been returned to newborn youth, using the induced pluripotent stem cell (iPSC) method of reprogramming cells to the pluripotent state. According to Science Daily, signs of aging were “erased” in these cells. They “recovered their capacity for self-renewal and their former differentiation potential, and do not preserve any traces of previous aging.” This means that age is not a barrier to reprogramming. Elders can imagine a fountain of youth: “This research paves the way for the therapeutic use of iPS, insofar as an ideal source of adult cells is provided, which are tolerated by the immune system and can repair organs or tissues in elderly patients.” Your personal fountain of youth: If your own skin cells can be rejuvenated fresh as a baby, why not bank them? In “Personal Stem Cell Banks Could Be Staple of Future Health Care,” Science Daily discussed that very possibility. Researchers at the University of Texas Health Science Center found that old stem cells can be rejuvenated by placing them in a young microenvironment. “This raises the possibility that patients’ own stem cells may one day be rescued and banked to treat their age-related diseases.” The Texans were apparently unaware of the work cited above that shows even centenarians donating cells that can be regenerated like new: “Older stem cells are not as robust as young ones,” this article claimed. If they are robust, why not store them like gold for a rainy day? Eternal cells: Ever since telomeres (like caps on the ends of chromosomes) were found to act as a countdown mechanism for cell division, researchers have been eager to know if their lifetimes can be extended. There is an enzyme, telomerase, that puts new telomeres on chromosomes, but usually just in embryonic cells. Medical Xpress reported that scientists at the German Cancer Research Center have found an alternate pathway for telomere lengthening. Research shows that some cancer cells use this alternate mechanism; that is why they keep dividing without limit. Learning how to prolong telomeres for good cells and arrest them for tumor cells is an important work in progress (see 9/25/2010). Checking checkpoints: Having checkpoints makes for good quality control in any engineering process. Remarkably, cells have checkpoints, too. Science Daily reported on work at the University of Warwick to study the “spindle checkpoint” in cell division that determines “How Daughter Cells Receive the Same Number of Chromosomes.” When that checkpoint is breached, aggressive cancer can result. The article quoted a member of the research team who said, “This cell division process is monitored by the body’s surveillance system known as the ‘spindle checkpoint’, and that is only switched off once everything within the cell is set up correctly. Amazingly, all of the elements of this process are conserved from yeast to human cells.” Much of biomedical research concerns finding ways to repair mutations to processes that were already there to prevent harm. The navigators: You don’t have to put a pyramid over your head, according to another article on Science Daily; you already have pyramid-shaped neurons in your cerebellum called “place cells” with a natural alternative to psychic powers. “Each place cell is activated at specific location of the environment and gives dynamic information about self-location relative to the external world,” the article said. “These neurons thus generate a cognitive map in the hippocampal system through the integration of multi sensory inputs combining external information (such as visual, auditory, olfactory and tactile cues) and inputs generated by self-motion (i.e. optic flow, proprioceptive [sense of limb position] and vestibular [inner-ear] information).” Scientists at Ruhr University learned this from mice, but it’s probably true of mice and men, and women, too. Internal sunscreen for that young look: Tanning: we’ve been warned too much is harmful. But the melanin in skin and eyes that darkens us upon exposure to ultraviolet light helps protect us, too. Medical Xpress said that while it takes days for UVB light to give that beach bronze look, our skin reacts much quicker to the more dangerous UVA – even within seconds. In the skin and the eye, with rhodopsin assisting, melanin production is triggered, absorbing UVA before it can lead to oxidative damage, and “converting it to a less harmful energy in the form of heat.” That’s what artificial sunscreens try to do anyway. Thankfully, your skin has heat sensors that remind you to get out of the sun. Rotary teamwork: ATP synthase made the news again in another wonderful way. The little rotary engines that generate ATP (the cell’s energy currency) work with other components that lubricate them. Science Daily reported work at Oxford University that learned how fatty acids interact with the engines. Sure enough, they “act as a ‘lubricant’ for the motor,” the scientists said. Maybe that gives the edge for the grand prize of 100% efficiency (see 10/14/2011). Rotary recycling: A cousin of ATP synthase is vacuolar ATP synthase (v-ATPase). It has the same rotary structure but spends ATP to pump protons into vacuoles and lysosomes, creating acidic conditions where cells break down and recycle used parts. In Science this week (334:6056, 11/04/2011, pp. 678-683, doi:10.1126/science.1207056), Zoncu et al. found an unexpected connection between v-ATPase and a protein complex in lysosomes named mTOR that is a “master growth regulator that is stimulated by amino acids.” Elaborating on its important role, they said, “This multicomponent protein kinase integrates inputs from growth factors as well as nutrient and energy supplies to control many biosynthetic and catabolic processes.” The team discovered that the rotary motor v-ATPase is intrinsically involved in an amino-acid signaling process that causes the mTOR complex 1 to translocate to the organelle surface. “These results identify the v-ATPase as a component of the mTOR pathway and delineate a lysosome-associated machinery for amino acid sensing,” the researchers said, thus recognizing v-ATPase having a more sophisticated role than just a proton pump. Apparently, the accumulation of amino acids in the lumen of the lysosome activates the motors to pump protons. This, in turn, puts the mTOR complex into action.
Award ceremony at Eurocrypt 2018: Krzysztof Pietrzak (left) und Bram Cohen (second from left) receive the Best Paper Award from Eurocrypt-chair Jesper Buus Nielsen (right). Credit: IST Austria Citation: Towards sustainable blockchains (2018, May 4) retrieved 18 July 2019 from https://phys.org/news/2018-05-sustainable-blockchains.html Bitcoin is by far the most successful digital currency. Its decentralized nature distinguishes it from all previously proposed digital currencies. Instead of having a central entity, all Bitcoin transactions are recorded in a public sequence of blocks known as a blockchain. To add a block to the blockchain, a user (or “miner”) needs to provide a “proof of work,” that is, they must solve a kind of cryptographic puzzle or challenge. As long as more than half of the computational power dedicated toward solving these puzzles is contributed by honest parties, the blockchain acts as robust, non-tamperable ledger that keeps track of all the Bitcoin transactions. Miners are incentivized by the promise of receiving Bitcoins as a reward for adding blocks, currently worth about U.S. $100,000 (about EUR 80,000) for every block found. This leads to massive energy use—by some estimates, the equivalent consumption of Denmark. But the problem is not only ecological, it is also economical. The high rewards required to incentivize miners will, in the long run, lead either to inflation or high transaction costs.,Researchers have been looking into alternatives to proofs of work for securing blockchains. “We believe the most promising approach is to use disk space,” says Krzysztof Pietrzak. “There exist massive amounts of unused disk space—in data centers, but also personal laptops and the like—which could be used for mining at almost no marginal cost.”Designing blockchains that use disk space instead of proofs of work is a challenging problem. A recent proposal, the Chia network (chia.net), will replace proofs of work with two key components.The first of these is “proofs of space,” which are used by miners to prove they dedicate disk space. As those proofs are extremely cheap to generate once the dedicated space has been initialized, another component is required to enforce a dynamic in which new blocks only appear every few minutes, similar to what occurs in Bitcoin. This second component uses what is called a “proof of sequential work” or “verifiable delay algorithm.” Essentially, this is a protocol where the user can show that they have done a long sequential computation upon receiving some sort of challenge. Being sequential means that—unlike “normal” proofs of work—having enormous amounts of computational power available does not make the computation any faster. Therefore, it serves as proof that a given amount of time has elapsed since the challenge has been received.In their award-winning paper, Cohen and Pietrzak construct the first practical and publicly verifiable proof of sequential work. Previous constructions either require the verifier to hold a secret trapdoor to verify a proof, or the prover to dedicate a massive amount of disk space to generate a proof.Existing algorithms were extremely complicated, or the proofs could only be verified by a party that had some kind of secret trapdoor, or the prover required a massive amount of disk space to generate a proof. Unfortunately, the new construction cannot be readily used for the main application the authors were interested in—blockchain designs—as it lacks one crucial property: uniqueness. In particular, a valid proof can be adapted into a different valid proof without having to repeat the sequential computation. This is a problem since the process to add a new block is like a lottery, and without the uniqueness property, an adversary could generate many different proofs of sequential work, and only announce the one that gives him the best chance of also winning this lottery in the next round. “Coming up with a design where proofs have a canonical representation without using heavy cryptographic machinery is an exciting open question,” says Pietrzak. This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Using a quantum blockchain to protect blockchains of the future Provided by Institute of Science and Technology Austria As blockchains become ever more popular and widespread, a growing concern is their sustainability. Current designs, most notably the blockchain underlying the Bitcoin cryptocurrency, are secured using so-called “proofs of work,” which requires huge amounts of computational power. This is an ecological problem challenging the long-term viability of cryptocurrencies. In an ongoing collaboration, Institute of Science and Technology Austria (IST Austria) Professor Krzysztof Pietrzak and BitTorrent inventor/Chia Network CEO Bram Cohen seek to address this problem by making use of disk space rather than computational work. Research into one of the two key components of this approach—”proofs of sequential work,” also known as “verifiable delay algorithms,” received this year’s Best Paper Award at EUROCRYPT, one of the world’s top two cryptography conferences. Explore further